Triptans

Scott C Armstrong; Kelly L Cozza

doi:10.1176/appi.psy.43.6.502

Triptans

Scott C Armstrong, Kelly L Cozza

Psychiatry

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Triptans are potent serotonin (5-HT) 1B/1D receptor agonists used to abort and treat migraine headaches. Although the triptans share pharmacodynamic characteristics at 5-HT(1B/1D) receptors, they differ pharmacokinetically. This column reviews how the triptans are metabolized. Generally, the triptans are metabolized by phase I monoamine oxidases (MAOs) and by various cytochrome p450 enzymes. However, each triptan has a unique metabolic profile, leading to significant differences in each triptan's potential for drug-drug interactions. These differences are detailed in this review.

Original language	English
Pages (from-to)	502-4
Number of pages	3
Journal	Psychosomatics
Volume	43
Issue number	6
DOIs	https://doi.org/10.1176/appi.psy.43.6.502
State	Published - 2002

Keywords

Drug Interactions
Humans
Migraine Disorders/drug therapy
Serotonin Receptor Agonists/therapeutic use

Access to Document

10.1176/appi.psy.43.6.502

Cite this

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title = "Triptans",

abstract = "Triptans are potent serotonin (5-HT) 1B/1D receptor agonists used to abort and treat migraine headaches. Although the triptans share pharmacodynamic characteristics at 5-HT(1B/1D) receptors, they differ pharmacokinetically. This column reviews how the triptans are metabolized. Generally, the triptans are metabolized by phase I monoamine oxidases (MAOs) and by various cytochrome p450 enzymes. However, each triptan has a unique metabolic profile, leading to significant differences in each triptan's potential for drug-drug interactions. These differences are detailed in this review.",

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AU - Armstrong, Scott C

AU - Cozza, Kelly L

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AB - Triptans are potent serotonin (5-HT) 1B/1D receptor agonists used to abort and treat migraine headaches. Although the triptans share pharmacodynamic characteristics at 5-HT(1B/1D) receptors, they differ pharmacokinetically. This column reviews how the triptans are metabolized. Generally, the triptans are metabolized by phase I monoamine oxidases (MAOs) and by various cytochrome p450 enzymes. However, each triptan has a unique metabolic profile, leading to significant differences in each triptan's potential for drug-drug interactions. These differences are detailed in this review.

KW - Drug Interactions

KW - Humans

KW - Migraine Disorders/drug therapy

KW - Serotonin Receptor Agonists/therapeutic use

U2 - 10.1176/appi.psy.43.6.502

DO - 10.1176/appi.psy.43.6.502

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