Abstract
Triptans are potent serotonin (5-HT) 1B/1D receptor agonists used to abort and treat migraine headaches. Although the triptans share pharmacodynamic characteristics at 5-HT(1B/1D) receptors, they differ pharmacokinetically. This column reviews how the triptans are metabolized. Generally, the triptans are metabolized by phase I monoamine oxidases (MAOs) and by various cytochrome p450 enzymes. However, each triptan has a unique metabolic profile, leading to significant differences in each triptan's potential for drug-drug interactions. These differences are detailed in this review.
| Original language | English |
|---|---|
| Pages (from-to) | 502-4 |
| Number of pages | 3 |
| Journal | Psychosomatics |
| Volume | 43 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2002 |
Keywords
- Drug Interactions
- Humans
- Migraine Disorders/drug therapy
- Serotonin Receptor Agonists/therapeutic use
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