ULTRA FLEXIBLE MACROPOROUS MICRONEEDLES FOR SUSTAINED DELIVERY OF (2R,6R)-HYDROXYNORKETAMINE

Riddha Das; Aydin Sadeqi; Caroline A. Browne; Irwin Lucki; Sameer Sonkusale

ULTRA FLEXIBLE MACROPOROUS MICRONEEDLES FOR SUSTAINED DELIVERY OF (2R,6R)-HYDROXYNORKETAMINE

Riddha Das, Aydin Sadeqi, Caroline A. Browne, Irwin Lucki, Sameer Sonkusale^*

^*Corresponding author for this work

Pharmacology and Molecular Therapeutics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Transdermal delivery using microneedles provides an alternative method to locally administer drug molecules with controlled release rate. In this study, our goal was to develop an ultra-flexible macro porous patch with hard microneedles that penetrate the skin. We demonstrated encapsulation of a non-hallucinogenic derivative of a dissociative anesthetic pharmaceutical, which is approved as a therapy for treatment resistant depression. The microneedles are made from biocompatible photo-curable resin. Solid formulation of this drug is encapsulated in the resin, which ensures high drug loading capacity. A flexible substrate is used as the backing to ensure skin conformability. The encapsulated drug molecules are released by diffusion in contact with interstitial fluid. Our findings demonstrate uniform encapsulation of the drug molecules into the resin and sufficient robustness of the microneedles to withstand the skin penetration forces.

Original language	English
Title of host publication	2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022
Editors	Reza Ghodssi, Jenna F. Chan
Publisher	Transducer Research Foundation
Pages	431-433
Number of pages	3
ISBN (Electronic)	9781940470047
State	Published - 2022
Event	2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022 - Hilton Head, United States Duration: 5 Jun 2022 → 9 Jun 2022

Publication series

Name	2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022

Conference

Conference	2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022
Country/Territory	United States
City	Hilton Head
Period	5/06/22 → 9/06/22

Keywords

drug delivery
laser cutting
laser lithography
Microneedle
post-traumatic stress disorder

Cite this

Das, R., Sadeqi, A., Browne, C. A., Lucki, I., & Sonkusale, S. (2022). ULTRA FLEXIBLE MACROPOROUS MICRONEEDLES FOR SUSTAINED DELIVERY OF (2R,6R)-HYDROXYNORKETAMINE. In R. Ghodssi, & J. F. Chan (Eds.), 2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022 (pp. 431-433). (2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022). Transducer Research Foundation.

Das, Riddha ; Sadeqi, Aydin ; Browne, Caroline A. et al. / ULTRA FLEXIBLE MACROPOROUS MICRONEEDLES FOR SUSTAINED DELIVERY OF (2R,6R)-HYDROXYNORKETAMINE. 2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022. editor / Reza Ghodssi ; Jenna F. Chan. Transducer Research Foundation, 2022. pp. 431-433 (2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022).

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title = "ULTRA FLEXIBLE MACROPOROUS MICRONEEDLES FOR SUSTAINED DELIVERY OF (2R,6R)-HYDROXYNORKETAMINE",

abstract = "Transdermal delivery using microneedles provides an alternative method to locally administer drug molecules with controlled release rate. In this study, our goal was to develop an ultra-flexible macro porous patch with hard microneedles that penetrate the skin. We demonstrated encapsulation of a non-hallucinogenic derivative of a dissociative anesthetic pharmaceutical, which is approved as a therapy for treatment resistant depression. The microneedles are made from biocompatible photo-curable resin. Solid formulation of this drug is encapsulated in the resin, which ensures high drug loading capacity. A flexible substrate is used as the backing to ensure skin conformability. The encapsulated drug molecules are released by diffusion in contact with interstitial fluid. Our findings demonstrate uniform encapsulation of the drug molecules into the resin and sufficient robustness of the microneedles to withstand the skin penetration forces.",

keywords = "drug delivery, laser cutting, laser lithography, Microneedle, post-traumatic stress disorder",

author = "Riddha Das and Aydin Sadeqi and Browne, {Caroline A.} and Irwin Lucki and Sameer Sonkusale",

note = "Publisher Copyright: {\textcopyright} 2022 TRF.; 2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022 ; Conference date: 05-06-2022 Through 09-06-2022",

year = "2022",

language = "English",

series = "2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022",

publisher = "Transducer Research Foundation",

pages = "431--433",

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booktitle = "2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022",

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Das, R, Sadeqi, A, Browne, CA, Lucki, I & Sonkusale, S 2022, ULTRA FLEXIBLE MACROPOROUS MICRONEEDLES FOR SUSTAINED DELIVERY OF (2R,6R)-HYDROXYNORKETAMINE. in R Ghodssi & JF Chan (eds), 2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022. 2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022, Transducer Research Foundation, pp. 431-433, 2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022, Hilton Head, United States, 5/06/22.

ULTRA FLEXIBLE MACROPOROUS MICRONEEDLES FOR SUSTAINED DELIVERY OF (2R,6R)-HYDROXYNORKETAMINE. / Das, Riddha; Sadeqi, Aydin; Browne, Caroline A. et al.
2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022. ed. / Reza Ghodssi; Jenna F. Chan. Transducer Research Foundation, 2022. p. 431-433 (2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Sadeqi, Aydin

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AU - Lucki, Irwin

AU - Sonkusale, Sameer

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N2 - Transdermal delivery using microneedles provides an alternative method to locally administer drug molecules with controlled release rate. In this study, our goal was to develop an ultra-flexible macro porous patch with hard microneedles that penetrate the skin. We demonstrated encapsulation of a non-hallucinogenic derivative of a dissociative anesthetic pharmaceutical, which is approved as a therapy for treatment resistant depression. The microneedles are made from biocompatible photo-curable resin. Solid formulation of this drug is encapsulated in the resin, which ensures high drug loading capacity. A flexible substrate is used as the backing to ensure skin conformability. The encapsulated drug molecules are released by diffusion in contact with interstitial fluid. Our findings demonstrate uniform encapsulation of the drug molecules into the resin and sufficient robustness of the microneedles to withstand the skin penetration forces.

AB - Transdermal delivery using microneedles provides an alternative method to locally administer drug molecules with controlled release rate. In this study, our goal was to develop an ultra-flexible macro porous patch with hard microneedles that penetrate the skin. We demonstrated encapsulation of a non-hallucinogenic derivative of a dissociative anesthetic pharmaceutical, which is approved as a therapy for treatment resistant depression. The microneedles are made from biocompatible photo-curable resin. Solid formulation of this drug is encapsulated in the resin, which ensures high drug loading capacity. A flexible substrate is used as the backing to ensure skin conformability. The encapsulated drug molecules are released by diffusion in contact with interstitial fluid. Our findings demonstrate uniform encapsulation of the drug molecules into the resin and sufficient robustness of the microneedles to withstand the skin penetration forces.

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KW - laser cutting

KW - laser lithography

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KW - post-traumatic stress disorder

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BT - 2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022

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Y2 - 5 June 2022 through 9 June 2022

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Das R, Sadeqi A, Browne CA, Lucki I, Sonkusale S. ULTRA FLEXIBLE MACROPOROUS MICRONEEDLES FOR SUSTAINED DELIVERY OF (2R,6R)-HYDROXYNORKETAMINE. In Ghodssi R, Chan JF, editors, 2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022. Transducer Research Foundation. 2022. p. 431-433. (2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022).