Understanding dengue virus evolution to support epidemic surveillance and counter-measure development

S. Pollett*, M. C. Melendrez, I. Maljkovic Berry, S. Duchêne, H. Salje, D. A.T. Cummings, R. G. Jarman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations

Abstract

Dengue virus (DENV) causes a profound burden of morbidity and mortality, and its global burden is rising due to the co-circulation of four divergent DENV serotypes in the ecological context of globalization, travel, climate change, urbanization, and expansion of the geographic range of the Ae.aegypti and Ae.albopictus vectors. Understanding DENV evolution offers valuable opportunities to enhance surveillance and response to DENV epidemics via advances in RNA virus sequencing, bioinformatics, phylogenetic and other computational biology methods. Here we provide a scoping overview of the evolution and molecular epidemiology of DENV and the range of ways that evolutionary analyses can be applied as a public health tool against this arboviral pathogen.

Original languageEnglish
Pages (from-to)279-295
Number of pages17
JournalInfection, Genetics and Evolution
Volume62
DOIs
StatePublished - Aug 2018

Keywords

  • Dengue virus
  • Evolution
  • Molecular epidemiology
  • Phylogenetics

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