Update on intervention versus medical therapy for atherosclerotic renal artery stenosis

Albeir Y. Mousa*, Ali F. Aburahma, Joseph Bozzay, Mike Broce, Mark Bates

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Atherosclerotic renal artery stenosis is known to be one of the most common causes of secondary hypertension, and early nonrandomized studies suggested that renal artery stenting (RASt) improved outcomes. The vascular community embraced this less invasive treatment alternative to surgery, and RASt increased in popularity during the late 1990s. However, recent randomized studies have failed to show a benefit regarding blood pressure or renal function when RASt was compared with best medical therapy, creating significant concerns about procedural efficacy. In the wake of these randomized trial results, hypertension and renal disease experts along with vascular interventional specialists now struggle with how to best manage atherosclerotic renal artery stenosis. This review objectively analyzes the current literature and highlights each trial's design weaknesses and strengths. We have provided our recommendations for contemporary treatment guidelines based on our interpretation of the available empirical data.

Original languageEnglish
Pages (from-to)1613-1623
Number of pages11
JournalJournal of Vascular Surgery
Issue number6
StatePublished - 1 Jun 2015
Externally publishedYes


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