Use of Biomarkers to Assess Environmental Exposures and Health Outcomes in Deployed Troops

Timothy M. Mallon; Pamela K. Krahl; Kevin M. Haines; Douglas I. Walker; Thomas Thatcher; Collynn F. Woeller; Juilee Thakar; Philip K. Hopke; Joel C. Gaydos; Mathew Ryan Smith; Karan Uppal; Young Mi Go; Dean P. Jones; Mark Utell

doi:10.1097/JOM.0000000000001752

Use of Biomarkers to Assess Environmental Exposures and Health Outcomes in Deployed Troops

Timothy M. Mallon^*, Pamela K. Krahl, Kevin M. Haines, Douglas I. Walker, Thomas Thatcher, Collynn F. Woeller, Juilee Thakar, Philip K. Hopke, Joel C. Gaydos, Mathew Ryan Smith, Karan Uppal, Young Mi Go, Dean P. Jones, Mark Utell

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Objective:This paper provides an overview of our Military Biomarkers Research Study (MBRS) designed to assess whether biomarkers can be used to retrospectively assess deployment exposures and health impacts related to deployment environmental exposures.Methods:The MBRS consists of four phases. Phase I was a feasibility study of stored sera. Phase II looks at associations between exposures and biomarkers. Phase III examines relationships of biomarkers and health outcomes, and Phase IV investigates in vitro biomarker changes associated with exposures to chemicals of interest. This paper briefly summarizes work already published and introduces the new reports contained in this supplement.Results:Novel biomarkers were identified. These were associated with deployment exposures.Conclusions:Significant associations were noted between deployment exposures, microRNA biomarkers and metabolomic biomarkers, and deployment health outcomes.

Original language	English
Pages (from-to)	S1-S4
Journal	Journal of Occupational and Environmental Medicine
Volume	61
DOIs	https://doi.org/10.1097/JOM.0000000000001752
State	Published - 1 Dec 2019
Externally published	Yes

Keywords

Department of Defense serum repository
burn pits
deployment surveillance
hazardous exposures
metabolomics
microRNAs
serum biomarkers

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10.1097/JOM.0000000000001752

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Mallon, T. M., Krahl, P. K., Haines, K. M., Walker, D. I., Thatcher, T., Woeller, C. F., Thakar, J., Hopke, P. K., Gaydos, J. C., Smith, M. R., Uppal, K., Go, Y. M., Jones, D. P., & Utell, M. (2019). Use of Biomarkers to Assess Environmental Exposures and Health Outcomes in Deployed Troops. Journal of Occupational and Environmental Medicine, 61, S1-S4. https://doi.org/10.1097/JOM.0000000000001752

@article{e8402c7e5f7b4100a5e3031b44662dfa,

title = "Use of Biomarkers to Assess Environmental Exposures and Health Outcomes in Deployed Troops",

abstract = "Objective:This paper provides an overview of our Military Biomarkers Research Study (MBRS) designed to assess whether biomarkers can be used to retrospectively assess deployment exposures and health impacts related to deployment environmental exposures.Methods:The MBRS consists of four phases. Phase I was a feasibility study of stored sera. Phase II looks at associations between exposures and biomarkers. Phase III examines relationships of biomarkers and health outcomes, and Phase IV investigates in vitro biomarker changes associated with exposures to chemicals of interest. This paper briefly summarizes work already published and introduces the new reports contained in this supplement.Results:Novel biomarkers were identified. These were associated with deployment exposures.Conclusions:Significant associations were noted between deployment exposures, microRNA biomarkers and metabolomic biomarkers, and deployment health outcomes.",

keywords = "Department of Defense serum repository, burn pits, deployment surveillance, hazardous exposures, metabolomics, microRNAs, serum biomarkers",

author = "Mallon, {Timothy M.} and Krahl, {Pamela K.} and Haines, {Kevin M.} and Walker, {Douglas I.} and Thomas Thatcher and Woeller, {Collynn F.} and Juilee Thakar and Hopke, {Philip K.} and Gaydos, {Joel C.} and Smith, {Mathew Ryan} and Karan Uppal and Go, {Young Mi} and Jones, {Dean P.} and Mark Utell",

note = "Publisher Copyright: {\textcopyright} 2019 American College of Occupational and Environmental Medicine. Unauthorized reproduction of this article is prohibited.",

year = "2019",

month = dec,

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doi = "10.1097/JOM.0000000000001752",

language = "English",

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Mallon, TM, Krahl, PK, Haines, KM, Walker, DI, Thatcher, T, Woeller, CF, Thakar, J, Hopke, PK, Gaydos, JC, Smith, MR, Uppal, K, Go, YM, Jones, DP & Utell, M 2019, 'Use of Biomarkers to Assess Environmental Exposures and Health Outcomes in Deployed Troops', Journal of Occupational and Environmental Medicine, vol. 61, pp. S1-S4. https://doi.org/10.1097/JOM.0000000000001752

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T1 - Use of Biomarkers to Assess Environmental Exposures and Health Outcomes in Deployed Troops

AU - Mallon, Timothy M.

AU - Krahl, Pamela K.

AU - Haines, Kevin M.

AU - Walker, Douglas I.

AU - Thatcher, Thomas

AU - Woeller, Collynn F.

AU - Thakar, Juilee

AU - Hopke, Philip K.

AU - Gaydos, Joel C.

AU - Smith, Mathew Ryan

AU - Uppal, Karan

AU - Go, Young Mi

AU - Jones, Dean P.

AU - Utell, Mark

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Objective:This paper provides an overview of our Military Biomarkers Research Study (MBRS) designed to assess whether biomarkers can be used to retrospectively assess deployment exposures and health impacts related to deployment environmental exposures.Methods:The MBRS consists of four phases. Phase I was a feasibility study of stored sera. Phase II looks at associations between exposures and biomarkers. Phase III examines relationships of biomarkers and health outcomes, and Phase IV investigates in vitro biomarker changes associated with exposures to chemicals of interest. This paper briefly summarizes work already published and introduces the new reports contained in this supplement.Results:Novel biomarkers were identified. These were associated with deployment exposures.Conclusions:Significant associations were noted between deployment exposures, microRNA biomarkers and metabolomic biomarkers, and deployment health outcomes.

AB - Objective:This paper provides an overview of our Military Biomarkers Research Study (MBRS) designed to assess whether biomarkers can be used to retrospectively assess deployment exposures and health impacts related to deployment environmental exposures.Methods:The MBRS consists of four phases. Phase I was a feasibility study of stored sera. Phase II looks at associations between exposures and biomarkers. Phase III examines relationships of biomarkers and health outcomes, and Phase IV investigates in vitro biomarker changes associated with exposures to chemicals of interest. This paper briefly summarizes work already published and introduces the new reports contained in this supplement.Results:Novel biomarkers were identified. These were associated with deployment exposures.Conclusions:Significant associations were noted between deployment exposures, microRNA biomarkers and metabolomic biomarkers, and deployment health outcomes.

KW - Department of Defense serum repository

KW - burn pits

KW - deployment surveillance

KW - hazardous exposures

KW - metabolomics

KW - microRNAs

KW - serum biomarkers

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Use of Biomarkers to Assess Environmental Exposures and Health Outcomes in Deployed Troops

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Keywords

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