Use of high-resolution MRI for investigation of fluid flow and global permeability in a material with interconnected porosity

Pascal Swider; Mark Conroy; Annaïg Pédrono; Dominique Ambard; Sue Mantell; Kjeld Søballe; Joan E. Bechtold

doi:10.1016/j.jbiomech.2006.10.002

Use of high-resolution MRI for investigation of fluid flow and global permeability in a material with interconnected porosity

Pascal Swider^*, Mark Conroy, Annaïg Pédrono, Dominique Ambard, Sue Mantell, Kjeld Søballe, Joan E. Bechtold

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

We present a multi-scale experimental approach designed to improve the investigation of both localized and global fluid flow in biomaterials with randomly interconnected porosity. Coralline hydroxyapatite (ProOsteon 500 from Interpore-Cross^®), having a relatively well-defined porosity, was used as an in vitro model of typical bone architecture. Axial fluid velocity profiles within the pores of a cylindrical hydroxyapatite sample were characterized using high-resolution MRI in conjunction with the measurement of global flow and associated permeability based on the Darcy-type relationship. Assuming Newtonian fluid behaviour, image analysis permitted computation of local porosity, intra-pore fluid shear, and visualization of flow heterogeneity within the sample. These results may benefit applications in biomaterials for the evaluation of factors influencing bony incorporation in porous scaffolds and on porous implant and bone surfaces. Normal and diseased biological tissues are also clinical relevant applications.

Original language	English
Pages (from-to)	2112-2118
Number of pages	7
Journal	Journal of Biomechanics
Volume	40
Issue number	9
DOIs	https://doi.org/10.1016/j.jbiomech.2006.10.002
State	Published - 2007
Externally published	Yes

Keywords

Bone substitute
Fluid velocity
High-resolution MR
Implant fixation
Permeability

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10.1016/j.jbiomech.2006.10.002

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title = "Use of high-resolution MRI for investigation of fluid flow and global permeability in a material with interconnected porosity",

abstract = "We present a multi-scale experimental approach designed to improve the investigation of both localized and global fluid flow in biomaterials with randomly interconnected porosity. Coralline hydroxyapatite (ProOsteon 500 from Interpore-Cross{\textregistered}), having a relatively well-defined porosity, was used as an in vitro model of typical bone architecture. Axial fluid velocity profiles within the pores of a cylindrical hydroxyapatite sample were characterized using high-resolution MRI in conjunction with the measurement of global flow and associated permeability based on the Darcy-type relationship. Assuming Newtonian fluid behaviour, image analysis permitted computation of local porosity, intra-pore fluid shear, and visualization of flow heterogeneity within the sample. These results may benefit applications in biomaterials for the evaluation of factors influencing bony incorporation in porous scaffolds and on porous implant and bone surfaces. Normal and diseased biological tissues are also clinical relevant applications.",

keywords = "Bone substitute, Fluid velocity, High-resolution MR, Implant fixation, Permeability",

author = "Pascal Swider and Mark Conroy and Anna{\"i}g P{\'e}drono and Dominique Ambard and Sue Mantell and Kjeld S{\o}balle and Bechtold, {Joan E.}",

year = "2007",

doi = "10.1016/j.jbiomech.2006.10.002",

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AU - Swider, Pascal

AU - Conroy, Mark

AU - Pédrono, Annaïg

AU - Ambard, Dominique

AU - Mantell, Sue

AU - Søballe, Kjeld

AU - Bechtold, Joan E.

PY - 2007

Y1 - 2007

N2 - We present a multi-scale experimental approach designed to improve the investigation of both localized and global fluid flow in biomaterials with randomly interconnected porosity. Coralline hydroxyapatite (ProOsteon 500 from Interpore-Cross®), having a relatively well-defined porosity, was used as an in vitro model of typical bone architecture. Axial fluid velocity profiles within the pores of a cylindrical hydroxyapatite sample were characterized using high-resolution MRI in conjunction with the measurement of global flow and associated permeability based on the Darcy-type relationship. Assuming Newtonian fluid behaviour, image analysis permitted computation of local porosity, intra-pore fluid shear, and visualization of flow heterogeneity within the sample. These results may benefit applications in biomaterials for the evaluation of factors influencing bony incorporation in porous scaffolds and on porous implant and bone surfaces. Normal and diseased biological tissues are also clinical relevant applications.

AB - We present a multi-scale experimental approach designed to improve the investigation of both localized and global fluid flow in biomaterials with randomly interconnected porosity. Coralline hydroxyapatite (ProOsteon 500 from Interpore-Cross®), having a relatively well-defined porosity, was used as an in vitro model of typical bone architecture. Axial fluid velocity profiles within the pores of a cylindrical hydroxyapatite sample were characterized using high-resolution MRI in conjunction with the measurement of global flow and associated permeability based on the Darcy-type relationship. Assuming Newtonian fluid behaviour, image analysis permitted computation of local porosity, intra-pore fluid shear, and visualization of flow heterogeneity within the sample. These results may benefit applications in biomaterials for the evaluation of factors influencing bony incorporation in porous scaffolds and on porous implant and bone surfaces. Normal and diseased biological tissues are also clinical relevant applications.

KW - Bone substitute

KW - Fluid velocity

KW - High-resolution MR

KW - Implant fixation

KW - Permeability

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SN - 0021-9290

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JO - Journal of Biomechanics

JF - Journal of Biomechanics

IS - 9

ER -

Use of high-resolution MRI for investigation of fluid flow and global permeability in a material with interconnected porosity

Abstract

Keywords

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