Utilization and outcomes of extracorporeal CO2 removal (ECCO2R): Systematic review and meta-analysis of arterio-venous and veno-venous ECCO2R approaches

Tiffany Z. Yu, Robert T. Tatum, Abhiraj Saxena, Danial Ahmad, Colin C. Yost, Elizabeth J. Maynes, Thomas J. O'Malley, Howard T. Massey, Justyna Swol, Bryan A. Whitson, Vakhtang Tchantchaleishvili*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Introduction: Extracorporeal carbon dioxide removal (ECCO2R) provides respiratory support to patients suffering from hypercapnic respiratory failure by utilizing an extracorporeal shunt and gas exchange membrane to remove CO2 from either the venous (VV-ECCO2R) or arterial (AV-ECCO2R) system before return into the venous site. AV-ECCO2R relies on the patient's native cardiac function to generate pressures needed to deliver blood through the extracorporeal circuit. VV-ECCO2R utilizes a mechanical pump and can be used to treat patients with inadequate native cardiac function. We sought to evaluate the existing evidence comparing the subgroups of patients supported on VV and AV-ECCO2R devices. Methods: A literature search was performed to identify all relevant studies published between 2000 and 2019. Demographic information, medical indications, perioperative variables, and clinical outcomes were extracted for systematic review and meta-analysis. Results: Twenty-five studies including 826 patients were reviewed. 60% of patients (497/826) were supported on VV-ECCO2R. The most frequent indications were acute respiratory distress syndrome (ARDS) [69%, (95%CI: 53%–82%)] and chronic obstructive pulmonary disease (COPD) [49%, (95%CI: 37%–60%)]. ICU length of stay was significantly shorter in patients supported on VV-ECCO2R compared to AV-ECCO2R [15 (95%CI: 7–23) vs. 42 (95%CI: 17–67) days, p = 0.05]. In-hospital mortality was not significantly different [27% (95%CI: 18%–38%) vs. 36% (95%CI: 24%–51%), p = 0.26]. Conclusion: Both VV and AV-ECCO2R provided clinically meaningful CO2 removal with comparable mortality.

Original languageEnglish
Pages (from-to)763-774
Number of pages12
JournalArtificial Organs
Issue number5
StatePublished - May 2022
Externally publishedYes


  • ARDS: acute respiratory distress syndrome
  • COPD: chronic obstructive pulmonary disease
  • ECCOR: extracorporeal carbon dioxide removal
  • bridge to lung transplantation
  • hypercapnic
  • respiratory failure


Dive into the research topics of 'Utilization and outcomes of extracorporeal CO2 removal (ECCO2R): Systematic review and meta-analysis of arterio-venous and veno-venous ECCO2R approaches'. Together they form a unique fingerprint.

Cite this