@article{e78dacc064c14d2ba1f42794c61603a6,
title = "Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys",
abstract = "Preclinical studies of human immunodeficiency virus type 1 (HIV-1) vaccine candidates have typically shown post-infection virological control, but protection against acquisition of infection has previously only been reported against neutralization-sensitive virus challenges. Here we demonstrate vaccine protection against acquisition of fully heterologous, neutralization-resistant simian immunodeficiency virus (SIV) challenges in rhesus monkeys. Adenovirus/poxvirus and adenovirus/adenovirus-vector-based vaccines expressing SIV SME543 Gag, Pol and Env antigens resulted in an 80\% or greater reduction in the per-exposure probability of infection against repetitive, intrarectal SIV MAC251 challenges in rhesus monkeys. Protection against acquisition of infection showed distinct immunological correlates compared with post-infection virological control and required the inclusion of Env in the vaccine regimen. These data demonstrate the proof-of-concept that optimized HIV-1 vaccine candidates can block acquisition of stringent, heterologous, neutralization-resistant virus challenges in rhesus monkeys.",
author = "Barouch, \{Dan H.\} and Jinyan Liu and Hualin Li and Maxfield, \{Lori F.\} and Peter Abbink and Lynch, \{Diana M.\} and Iampietro, \{M. Justin\} and Adam Sanmiguel and Seaman, \{Michael S.\} and Guido Ferrari and Forthal, \{Donald N.\} and Ilnour Ourmanov and Hirsch, \{Vanessa M.\} and Angela Carville and Mansfield, \{Keith G.\} and Donald Stablein and Pau, \{Maria G.\} and Hanneke Schuitemaker and Sadoff, \{Jerald C.\} and Billings, \{Erik A.\} and Mangala Rao and Merlin Robb and Kim, \{Jerome H.\} and Marovich, \{Mary A.\} and Jaap Goudsmit and Michael, \{Nelson L.\}",
note = "Funding Information: Acknowledgements We thank M. Pensiero, A. Fauci, E. Borducchi, S. Clark, R. Hamel, S. King, P. Kozlowski, A. La Porte, G. Landucci, A. Oza, J. Perry, L. Peter, A. Riggs, G. Shaw, N. Simmons, K. Smith, K. Stanley, F. Stephens, Y.-H. Sun, G. Weverling and E. Zablowsky for advice, assistance and reagents. We thank L. Picker, G. Silvestri and B. Walker for critically reviewing this manuscript. The SIVMAC239 peptide pools were obtained from the NIH AIDS Research and Reference Reagent Program. We acknowledge support from the US Military Research and Material Command and the US Military HIV Research Program (W81XWH-07-2-0067); the Ragon Institute of MGH, MIT and Harvard; the National Institutes of Health (AI066924, AI078526, AI084794, AI095985, AI060354, AI002642, RR000168); and the Bill and Melinda Gates Foundation. The opinions in this manuscript are those of the authors and do not reflect the views of the US Department of Defense.",
year = "2012",
month = feb,
day = "2",
doi = "10.1038/nature10766",
language = "English",
volume = "482",
pages = "89--93",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Research",
number = "7383",
}