Abstract
We describe the validation of a serum-based test developed by Rules-Based Medicine which can be used to help confirm the diagnosis of schizophrenia. In preliminary studies using multiplex immunoassay profiling technology, we identified a disease signature comprised of 51 analytes which could distinguish schizophrenia (n = 250) from control (n = 230) subjects. In the next stage, these analytes were developed as a refined 51-plex immunoassay panel for validation using a large independent cohort of schizophrenia (n = 577) and control (n = 229) subjects. The resulting test yielded an overall sensitivity of 83% and specificity of 83% with a receiver operating characteristic area under the curve (ROC-AUC) of 89%. These 51 immunoassays and the associated decision rule delivered a sensitive and specific prediction for the presence of schizophrenia in patients compared to matched healthy controls.
Original language | English |
---|---|
Pages (from-to) | 39-47 |
Number of pages | 9 |
Journal | Biomarker Insights |
Volume | 2010 |
Issue number | 5 |
DOIs | |
State | Published - 2010 |
Externally published | Yes |
Keywords
- Diagnosis
- Schizophrenia
- Serum-based test