TY - JOUR
T1 - Validation of a Culturally Relevant Snakebite Envenomation Clinical Practice Guideline in Brazil
AU - Rocha, Gisele Dos Santos
AU - Farias, Altair Seabra
AU - Alcântara, João Arthur
AU - Machado, Vinícius Azevedo
AU - Murta, Felipe
AU - Val, Fernando
AU - Cristino, Joseir Saturnino
AU - Santos, Alícia Cacau
AU - Ferreira, Mena Bianca
AU - Marques, Leonardo
AU - Rocha, Yasmim Vieira
AU - Sachett, André
AU - Almeida, Mailma Costa
AU - Alencar, Aline
AU - Brasileiro, Lisele
AU - Carvalho, Érica da Silva
AU - Bisneto, Pedro Ferreira
AU - Lacerda, Marcus
AU - Tupetz, Anna
AU - Staton, Catherine A.
AU - Vissoci, João R.N.
AU - Teixeira, Elizabeth
AU - Gerardo, Charles J.
AU - Wen, Fan Hui
AU - Sachett, Jacqueline
AU - Monteiro, Wuelton
N1 - Funding Information:
Funding: M.L., J.S. and W.M.M. were funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq productivity scholarships). W.M. was funded by Fundação de Amparo à Pesquisa do Estado do Amazonas (PRÓ-ESTADO, call No. 011/2021-PCGP/FAPEAM, call No. 010/2021-CT&I ÁREAS PRIORITÁRIAS and POSGRAD) and by the Ministry of Health, Brazil (proposal No. 733781/19-035). F.M. is funded by Fiocruz (Inova scholarship). C.J.G. receives research funding, and the research reported in this publication was partly supported by the Fogarty International Center of the National Institutes of Health under Award Number R21TW011944. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Funding Information:
M.L., J.S. and W.M.M. were funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq productivity scholarships). W.M. was funded by Fundação de Amparo à Pesquisa do Estado do Amazonas (PRÓ-ESTADO, call No. 011/2021-PCGP/FAPEAM, call No. 010/2021CT&I ÁREAS PRIORITÁRIAS and POSGRAD) and by the Ministry of Health, Brazil (proposal No. 733781/19-035). F.M. is funded by Fiocruz (Inova scholarship). C.J.G. receives research funding, and the research reported in this publication was partly supported by the Fogarty International Center of the National Institutes of Health under Award Number R21TW011944. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/6
Y1 - 2022/6
N2 - Snakebite envenoming (SBE) is a neglected tropical disease with significant global morbidity and mortality. Even when antivenom is available in low-resource areas, health workers do not receive adequate training to manage SBEs. This study aims to develop and validate a clinical practice guideline (CPG) for SBE management across Brazil. A panel of expert judges with academic and/or technical expertise in SBE management performed content validation. The content validity index (CVI) score was 90% for CPG objectives, 89% for structure and presentation and 92% for relevance and classified the CPG as valid. A semantic validation was performed by analyzing focus group discussions with doctors and nurses from three municipalities of the Brazilian Amazon, after a 5-day meeting during which the CPG was presented. Two central themes emerged: knowledge acquired during the meeting and recommendations for improving the CPG. Based on these results, the CPG was revised into a final version. This study presents the successful development and validation process of a CPG for SBE management, which is targeted to a specific low-resource, high-burden setting. This development and validation process can be adapted to other settings and/or other neglected tropical diseases.
AB - Snakebite envenoming (SBE) is a neglected tropical disease with significant global morbidity and mortality. Even when antivenom is available in low-resource areas, health workers do not receive adequate training to manage SBEs. This study aims to develop and validate a clinical practice guideline (CPG) for SBE management across Brazil. A panel of expert judges with academic and/or technical expertise in SBE management performed content validation. The content validity index (CVI) score was 90% for CPG objectives, 89% for structure and presentation and 92% for relevance and classified the CPG as valid. A semantic validation was performed by analyzing focus group discussions with doctors and nurses from three municipalities of the Brazilian Amazon, after a 5-day meeting during which the CPG was presented. Two central themes emerged: knowledge acquired during the meeting and recommendations for improving the CPG. Based on these results, the CPG was revised into a final version. This study presents the successful development and validation process of a CPG for SBE management, which is targeted to a specific low-resource, high-burden setting. This development and validation process can be adapted to other settings and/or other neglected tropical diseases.
KW - antivenom
KW - clinical practice guideline
KW - health education
KW - snakebite
KW - validation
UR - http://www.scopus.com/inward/record.url?scp=85131383641&partnerID=8YFLogxK
U2 - 10.3390/toxins14060376
DO - 10.3390/toxins14060376
M3 - Article
AN - SCOPUS:85131383641
SN - 2072-6651
VL - 14
JO - Toxins
JF - Toxins
IS - 6
M1 - 376
ER -