TY - JOUR
T1 - Validation of a Culturally Relevant Snakebite Envenomation Clinical Practice Guideline in Brazil
AU - Rocha, Gisele Dos Santos
AU - Farias, Altair Seabra
AU - Alcântara, João Arthur
AU - Machado, Vinícius Azevedo
AU - Murta, Felipe
AU - Val, Fernando
AU - Cristino, Joseir Saturnino
AU - Santos, Alícia Cacau
AU - Ferreira, Mena Bianca
AU - Marques, Leonardo
AU - Rocha, Yasmim Vieira
AU - Sachett, André
AU - Almeida, Mailma Costa
AU - Alencar, Aline
AU - Brasileiro, Lisele
AU - Carvalho, Érica da Silva
AU - Bisneto, Pedro Ferreira
AU - Lacerda, Marcus
AU - Tupetz, Anna
AU - Staton, Catherine A.
AU - Vissoci, João R.N.
AU - Teixeira, Elizabeth
AU - Gerardo, Charles J.
AU - Wen, Fan Hui
AU - Sachett, Jacqueline
AU - Monteiro, Wuelton
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/5/28
Y1 - 2022/5/28
N2 - Snakebite envenoming (SBE) is a neglected tropical disease with significant global morbidity and mortality. Even when antivenom is available in low-resource areas, health workers do not receive adequate training to manage SBEs. This study aims to develop and validate a clinical practice guideline (CPG) for SBE management across Brazil. A panel of expert judges with academic and/or technical expertise in SBE management performed content validation. The content validity index (CVI) score was 90% for CPG objectives, 89% for structure and presentation and 92% for relevance and classified the CPG as valid. A semantic validation was performed by analyzing focus group discussions with doctors and nurses from three municipalities of the Brazilian Amazon, after a 5-day meeting during which the CPG was presented. Two central themes emerged: knowledge acquired during the meeting and recommendations for improving the CPG. Based on these results, the CPG was revised into a final version. This study presents the successful development and validation process of a CPG for SBE management, which is targeted to a specific low-resource, high-burden setting. This development and validation process can be adapted to other settings and/or other neglected tropical diseases.
AB - Snakebite envenoming (SBE) is a neglected tropical disease with significant global morbidity and mortality. Even when antivenom is available in low-resource areas, health workers do not receive adequate training to manage SBEs. This study aims to develop and validate a clinical practice guideline (CPG) for SBE management across Brazil. A panel of expert judges with academic and/or technical expertise in SBE management performed content validation. The content validity index (CVI) score was 90% for CPG objectives, 89% for structure and presentation and 92% for relevance and classified the CPG as valid. A semantic validation was performed by analyzing focus group discussions with doctors and nurses from three municipalities of the Brazilian Amazon, after a 5-day meeting during which the CPG was presented. Two central themes emerged: knowledge acquired during the meeting and recommendations for improving the CPG. Based on these results, the CPG was revised into a final version. This study presents the successful development and validation process of a CPG for SBE management, which is targeted to a specific low-resource, high-burden setting. This development and validation process can be adapted to other settings and/or other neglected tropical diseases.
KW - Antivenins/therapeutic use
KW - Brazil
KW - Health Personnel
KW - Humans
KW - Practice Guidelines as Topic
KW - Snake Bites/diagnosis
UR - https://www.scopus.com/pages/publications/85131383641
U2 - 10.3390/toxins14060376
DO - 10.3390/toxins14060376
M3 - Article
C2 - 35737037
AN - SCOPUS:85131383641
SN - 2072-6651
VL - 14
JO - Toxins
JF - Toxins
IS - 6
M1 - 376
ER -