Venous thromboembolism after trauma

M. Margaret Knudson*, Danagra G. Ikossi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

94 Scopus citations


Purpose of review: The trauma population is at increased risk of venous thromboembolic disease, a potentially preventable cause of mortality and morbidity. Although the association between trauma and venous thromboembolism has been recognized for more than a century, there is still great variability in the clinical practices with respect to prophylaxis. This thorough review of recent literature aims to clarify the incidence and risk factors for deep venous thrombosis and pulmonary embolism after trauma, review options and recommendations for detection of deep venous thrombosis and pulmonary embolism, and give evidence-based recommendations for prophylaxis. Special attention is paid to patients with spinal cord injury, patients with head injury, and pediatric trauma patients. Recent findings: Highlights in this field during the past year include stratification of venous thromboembolism risk factors after trauma using a large national database, the expanded use of venous duplex ultrasound surveillance in the ICU and during rehabilitation, and investigations into the safety of low molecular weight heparins in patients with solid organ and traumatic brain injuries. Additionally, two new classes of anticoagulant drugs have been introduced for venous thromboembolism prophylaxis, and there are some preliminary studies on a temporary vena cava filter for the prevention of pulmonary embolism. Summary: Venous thromboembolism remains an area of active clinical research focusing on evolving diagnostic techniques, newer methods of chemical and mechanical prophylaxis, and improved understanding of the etiologic factors of posttraumatic venous thromboembolism. These efforts will undoubtedly decrease the posttraumatic morbidity and mortality associated with venous thromboembolism.

Original languageEnglish
Pages (from-to)539-548
Number of pages10
JournalCurrent Opinion in Critical Care
Issue number6
StatePublished - Dec 2004
Externally publishedYes


  • Deep venous thrombosis
  • Pulmonary embolism
  • Trauma
  • Venous thromboembolism


Dive into the research topics of 'Venous thromboembolism after trauma'. Together they form a unique fingerprint.

Cite this