Vertebrate embryos as tools for anti-angiogenic drug screening and function

Shaunna L. Beedie, Alexandra J. Diamond, Lucas Rosa Fraga, William D. Figg, Neil Vargesson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The development of new angiogenic inhibitors highlights a need for robust screening assays that adequately capture the complexity of vessel formation, and allow for the quantitative evaluation of the teratogenicity of new anti-angiogenic agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.

Original languageEnglish
Pages (from-to)49-59
Number of pages11
JournalReproductive Toxicology
Volume70
DOIs
StatePublished - Jun 2017
Externally publishedYes

Keywords

  • Angiogenesis
  • Chicken
  • Mouse
  • Non-human primates
  • Rabbit
  • Rat
  • Thalidomide
  • Zebrafish

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