Vertebrate embryos as tools for anti-angiogenic drug screening and function

Shaunna L. Beedie; Alexandra J. Diamond; Lucas Rosa Fraga; William D. Figg; Neil Vargesson

doi:10.1016/j.reprotox.2016.11.013

Vertebrate embryos as tools for anti-angiogenic drug screening and function

Shaunna L. Beedie, Alexandra J. Diamond, Lucas Rosa Fraga, William D. Figg, Neil Vargesson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The development of new angiogenic inhibitors highlights a need for robust screening assays that adequately capture the complexity of vessel formation, and allow for the quantitative evaluation of the teratogenicity of new anti-angiogenic agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.

Original language	English
Pages (from-to)	49-59
Number of pages	11
Journal	Reproductive Toxicology
Volume	70
DOIs	https://doi.org/10.1016/j.reprotox.2016.11.013
State	Published - Jun 2017
Externally published	Yes

Keywords

Angiogenesis
Chicken
Mouse
Non-human primates
Rabbit
Rat
Thalidomide
Zebrafish

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10.1016/j.reprotox.2016.11.013

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abstract = "The development of new angiogenic inhibitors highlights a need for robust screening assays that adequately capture the complexity of vessel formation, and allow for the quantitative evaluation of the teratogenicity of new anti-angiogenic agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.",

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author = "Beedie, {Shaunna L.} and Diamond, {Alexandra J.} and Fraga, {Lucas Rosa} and Figg, {William D.} and Neil Vargesson",

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AU - Beedie, Shaunna L.

AU - Diamond, Alexandra J.

AU - Fraga, Lucas Rosa

AU - Figg, William D.

AU - Vargesson, Neil

PY - 2017/6

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AB - The development of new angiogenic inhibitors highlights a need for robust screening assays that adequately capture the complexity of vessel formation, and allow for the quantitative evaluation of the teratogenicity of new anti-angiogenic agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.

KW - Angiogenesis

KW - Chicken

KW - Mouse

KW - Non-human primates

KW - Rabbit

KW - Rat

KW - Thalidomide

KW - Zebrafish

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ER -

Vertebrate embryos as tools for anti-angiogenic drug screening and function

Abstract

Keywords

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