Vertebrate embryos as tools for anti-angiogenic drug screening and function

Shaunna L. Beedie; Alexandra J. Diamond; Lucas Rosa Fraga; William D. Figg; Neil Vargesson

doi:10.1016/j.reprotox.2016.11.013

Vertebrate embryos as tools for anti-angiogenic drug screening and function

Shaunna L. Beedie
, Alexandra J. Diamond
, Lucas Rosa Fraga
, William D. Figg
, Neil Vargesson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The development of new angiogenic inhibitors highlights a need for robust screening assays that adequately capture the complexity of vessel formation, and allow for the quantitative evaluation of the teratogenicity of new anti-angiogenic agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.

Original language	English
Pages (from-to)	49-59
Number of pages	11
Journal	Reproductive Toxicology
Volume	70
DOIs	https://doi.org/10.1016/j.reprotox.2016.11.013
State	Published - Jun 2017
Externally published	Yes

Keywords

Angiogenesis
Chicken
Mouse
Non-human primates
Rabbit
Rat
Thalidomide
Zebrafish

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10.1016/j.reprotox.2016.11.013

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title = "Vertebrate embryos as tools for anti-angiogenic drug screening and function",

abstract = "The development of new angiogenic inhibitors highlights a need for robust screening assays that adequately capture the complexity of vessel formation, and allow for the quantitative evaluation of the teratogenicity of new anti-angiogenic agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.",

keywords = "Angiogenesis, Chicken, Mouse, Non-human primates, Rabbit, Rat, Thalidomide, Zebrafish",

author = "Beedie, \{Shaunna L.\} and Diamond, \{Alexandra J.\} and Fraga, \{Lucas Rosa\} and Figg, \{William D.\} and Neil Vargesson",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2017",

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doi = "10.1016/j.reprotox.2016.11.013",

language = "English",

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AU - Beedie, Shaunna L.

AU - Diamond, Alexandra J.

AU - Fraga, Lucas Rosa

AU - Figg, William D.

AU - Vargesson, Neil

PY - 2017/6

Y1 - 2017/6

N2 - The development of new angiogenic inhibitors highlights a need for robust screening assays that adequately capture the complexity of vessel formation, and allow for the quantitative evaluation of the teratogenicity of new anti-angiogenic agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.

AB - The development of new angiogenic inhibitors highlights a need for robust screening assays that adequately capture the complexity of vessel formation, and allow for the quantitative evaluation of the teratogenicity of new anti-angiogenic agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.

KW - Angiogenesis

KW - Chicken

KW - Mouse

KW - Non-human primates

KW - Rabbit

KW - Rat

KW - Thalidomide

KW - Zebrafish

UR - https://www.scopus.com/pages/publications/85007287409

U2 - 10.1016/j.reprotox.2016.11.013

DO - 10.1016/j.reprotox.2016.11.013

M3 - Article

C2 - 27888069

AN - SCOPUS:85007287409

SN - 0890-6238

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SP - 49

EP - 59

JO - Reproductive Toxicology

JF - Reproductive Toxicology

ER -

Vertebrate embryos as tools for anti-angiogenic drug screening and function

Abstract

Keywords

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