Viability and biodistribution of68Ga MPO-labelled human platelets

D. A. Goodwin*, E. V. Lang, J. E. Atwood, R. L. Dalman, C. Mc K. Ransone, C. I. Diamanti, M. Mc Tigue

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The viability and biodistribution of 68Ga-mercaptopyridine-iVoxide (MPO)-Iabelled autologous platelets was studied in 10 patients. The average platelet labelling yield was 36 ± 12% and injected activity was 2.0 ± 0.9 mCi68Ga. The % activity in platelets per ml whole blood was 64 ± 20% at 15 min-1.0 h postinjection and 76 ± 14% at 2-4 h. The average recovery of platelets (% injected platelets circulating in peripheral blood) was 31 ± 21% at 15 min-1h and 39 ± 20% at 2-4 h. The positron emission tomographic (PF.T) images showed high circulating vascular background. Two patients had technically inadequate scans, and six w'ere false negative due to high blood background. One patient with a massive pulmonary embolus occurring 24 h prior to scanning had marked uptake of 68Ga platelets in a large clot in the superior branch of the right main pulmonary artery. A second patient, with 6SGa platelets circulating during angioplasty of a left posterior tibial artery stenosis, had intense uptake in the lesion shown on the PET scan obtained 4 h following the procedure. These results indicate good viability of 68Ga-MPO-Iabelled autologous human platelets, but poor visualization of clots by PET imaging, due to the high blood background at early times.

Original languageEnglish
Pages (from-to)1023-1029
Number of pages7
JournalNuclear Medicine Communications
Issue number11
StatePublished - Nov 1993
Externally publishedYes


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