Viral trans-dominant manipulation of algal sphingolipids

Louise V. Michaelson; Teresa M. Dunn; Johnathan A. Napier

doi:10.1016/j.tplants.2010.09.004

Viral trans-dominant manipulation of algal sphingolipids

Louise V. Michaelson, Teresa M. Dunn, Johnathan A. Napier^*

^*Corresponding author for this work

Biochemistry

Research output: Contribution to journal › Short survey › peer-review

19 Scopus citations

Abstract

Emiliania huxleyi is the host for the coccolithovirus (EhV), which is responsible for the demise of large oceanic blooms formed by this alga. The EhV-86 virus genome sequence has identified several genes apparently involved in sphingolipid metabolism. Recently, an unusual glucosylceramide from E. huxleyi infected with EhV-86 was isolated, implicating sphingolipids in the lysis of this alga. However, the EhV-86-encoded genes contain only a subset of the activities required to generate the novel sphingolipid, implying that its synthesis is the result of coordinated interactions between algal- and viral-encoded biosynthetic enzymes. Here, we discuss the likely role for EhV-86 open reading frames (ORFs) in the synthesis of novel sphingolipids and also consider the concept of the trans-dominant manipulation of lipid metabolism.

Original language	English
Pages (from-to)	651-655
Number of pages	5
Journal	Trends in Plant Science
Volume	15
Issue number	12
DOIs	https://doi.org/10.1016/j.tplants.2010.09.004
State	Published - Dec 2010

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10.1016/j.tplants.2010.09.004

Cite this

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title = "Viral trans-dominant manipulation of algal sphingolipids",

abstract = "Emiliania huxleyi is the host for the coccolithovirus (EhV), which is responsible for the demise of large oceanic blooms formed by this alga. The EhV-86 virus genome sequence has identified several genes apparently involved in sphingolipid metabolism. Recently, an unusual glucosylceramide from E. huxleyi infected with EhV-86 was isolated, implicating sphingolipids in the lysis of this alga. However, the EhV-86-encoded genes contain only a subset of the activities required to generate the novel sphingolipid, implying that its synthesis is the result of coordinated interactions between algal- and viral-encoded biosynthetic enzymes. Here, we discuss the likely role for EhV-86 open reading frames (ORFs) in the synthesis of novel sphingolipids and also consider the concept of the trans-dominant manipulation of lipid metabolism.",

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AU - Dunn, Teresa M.

AU - Napier, Johnathan A.

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AB - Emiliania huxleyi is the host for the coccolithovirus (EhV), which is responsible for the demise of large oceanic blooms formed by this alga. The EhV-86 virus genome sequence has identified several genes apparently involved in sphingolipid metabolism. Recently, an unusual glucosylceramide from E. huxleyi infected with EhV-86 was isolated, implicating sphingolipids in the lysis of this alga. However, the EhV-86-encoded genes contain only a subset of the activities required to generate the novel sphingolipid, implying that its synthesis is the result of coordinated interactions between algal- and viral-encoded biosynthetic enzymes. Here, we discuss the likely role for EhV-86 open reading frames (ORFs) in the synthesis of novel sphingolipids and also consider the concept of the trans-dominant manipulation of lipid metabolism.

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