Vitamin C in Burn Resuscitation

Julie A. Rizzo*, Matthew P. Rowan, Ian R. Driscoll, Kevin K. Chung, Bruce C. Friedman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


The inflammatory state after burn injury is characterized by an increase in capillary permeability that results in protein and fluid leakage into the interstitial space, increasing resuscitative requirements. Although the mechanisms underlying increased capillary permeability are complex, damage from reactive oxygen species plays a major role and has been successfully attenuated with antioxidant therapy in several disease processes. However, the utility of antioxidants in burn treatment remains unclear. Vitamin C is a promising antioxidant candidate that has been examined in burn resuscitation studies and shows efficacy in reducing the fluid requirements in the acute phase after burn injury.

Original languageEnglish
Pages (from-to)539-546
Number of pages8
JournalCritical Care Clinics
Issue number4
StatePublished - 1 Oct 2016
Externally publishedYes


  • Ascorbic acid
  • Burn
  • Free radical
  • Reactive oxygen species
  • Vitamin C


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