Vulvovaginal and ocular involvement and treatment in female patients with Stevens–Johnson syndrome and toxic epidermal necrolysis: A review

M. Teresa Magone; Mary Maiberger; Janine Clayton; Helena Pasieka

doi:10.1016/j.ijwd.2021.08.012

Vulvovaginal and ocular involvement and treatment in female patients with Stevens–Johnson syndrome and toxic epidermal necrolysis: A review

M. Teresa Magone^*, Mary Maiberger, Janine Clayton, Helena Pasieka

^*Corresponding author for this work

Dermatology

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious adverse cutaneous drug reactions, characterized by epidermal detachment and mucous membrane involvement. SJS/TEN is more common in female patients, with unique findings in the ocular and vulvar regions. Early recognition and intervention, as well as long-term follow-up, are crucial to prevent devastating scarring and sequelae. This review examines the vulvar and ocular manifestations of SJS/TEN and describes the current treatment recommendations for female patients, requiring close consultation and collaboration among dermatology, ophthalmology, and gynecology.

Original language	English
Pages (from-to)	520-528
Number of pages	9
Journal	International Journal of Women's Dermatology
Volume	7
Issue number	5
DOIs	https://doi.org/10.1016/j.ijwd.2021.08.012
State	Published - Dec 2021

Keywords

Stevens–Johnson syndrome
cutaneous drug eruption
dry eye
ocular-surface
toxic epidermal necrolysis
vulvar involvement

Access to Document

10.1016/j.ijwd.2021.08.012

Cite this

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title = "Vulvovaginal and ocular involvement and treatment in female patients with Stevens–Johnson syndrome and toxic epidermal necrolysis: A review",

abstract = "Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious adverse cutaneous drug reactions, characterized by epidermal detachment and mucous membrane involvement. SJS/TEN is more common in female patients, with unique findings in the ocular and vulvar regions. Early recognition and intervention, as well as long-term follow-up, are crucial to prevent devastating scarring and sequelae. This review examines the vulvar and ocular manifestations of SJS/TEN and describes the current treatment recommendations for female patients, requiring close consultation and collaboration among dermatology, ophthalmology, and gynecology.",

keywords = "Stevens–Johnson syndrome, cutaneous drug eruption, dry eye, ocular-surface, toxic epidermal necrolysis, vulvar involvement",

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T1 - Vulvovaginal and ocular involvement and treatment in female patients with Stevens–Johnson syndrome and toxic epidermal necrolysis

T2 - A review

AU - Magone, M. Teresa

AU - Maiberger, Mary

AU - Clayton, Janine

AU - Pasieka, Helena

PY - 2021/12

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AB - Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious adverse cutaneous drug reactions, characterized by epidermal detachment and mucous membrane involvement. SJS/TEN is more common in female patients, with unique findings in the ocular and vulvar regions. Early recognition and intervention, as well as long-term follow-up, are crucial to prevent devastating scarring and sequelae. This review examines the vulvar and ocular manifestations of SJS/TEN and describes the current treatment recommendations for female patients, requiring close consultation and collaboration among dermatology, ophthalmology, and gynecology.

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KW - cutaneous drug eruption

KW - dry eye

KW - ocular-surface

KW - toxic epidermal necrolysis

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