An overwhelming consensus exists that wear particles are the primary driving force in aseptic loosening of orthopaedic implants. Nonetheless, considerable evidence has emerged demonstrating that various other factors can modulate the biologic activity of orthopaedic wear particles. Two of the most studied modulating factors are bacterial endotoxins and implant motion.
|Journal||The Journal of the American Academy of Orthopaedic Surgeons|
|Volume||16 Suppl 1|
|State||Published - 2008|