Whole or Partial Vessel Outgrowth Assays

Cindy H. Chau*, William D. Figg

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations


In recent years, the assessment of angiogenesis has often involved the use of whole or partial vessel outgrowth assays such as that of the rat aortic ring, chick aortic arch, porcine carotid artery, human saphenous vein, placental vein disc, foetal mouse bone explant and rat vena cava model. The development of this ex vivo organ culture method closely recapitulates the complexities of angiogenesis, forming a bridge between in vitro and in vivo studies. Herein we will provide detailed descriptions of the individual assays followed by a discussion of their unique strengths and weaknesses. We will also highlight the emergence of recent developments and applications of this methodology that have been incorporated into common practice.

Original languageEnglish
Title of host publicationAngiogenesis Assays
Subtitle of host publicationA Critical Appraisal of Current Techniques
PublisherJohn Wiley & Sons, Ltd
Number of pages17
ISBN (Print)0470016000, 9780470016008
StatePublished - 27 Sep 2007
Externally publishedYes


  • Angiogenesis quantification in organ culture assays
  • Aortic ring assay
  • Aortic ring organ-culture system
  • Chick aortic arch assay
  • Human explant cultures
  • Microarray technology
  • Quantitative angiogenic assays
  • Whole or partial vessel outgrowth assays


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