Workshop on late renal allograft dysfunction

Catherine M. Meyers*, Allan D. Kirk

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Despite continued improvement in incidence of acute immune injury and short-term graft survival, late allograft dysfunction remains a significant problem in the renal transplant population. Recent reports suggest that rates of renal function decline are quite varied in the overall recipient population, and that individual rates for many recipients may not change substantially over time. Moreover, analyses also reveal distinct predictive factors for both early and late functional decline. Long-term outcome studies for renal transplantation, however, might be significantly limited by incomplete data sets for assessing clinical endpoints. In view of the heterogeneous factors that may cause progressive allograft injury, more routine biopsy sampling would allow a more complete characterization of induced injuries. Elucidating mechanisms of renal fibrosis in response to injury, in experimental systems and humans, is also an important goal in better understanding chronic allograft damage. Regulation of cell senescence genes and epithelial to mesenchymal transition, studied in other models of renal fibrosis, are likely relevant to studies of renal allograft dysfunction. Recent technical advances in analyzing biological samples may play a pivotal role in identifying and validating surrogate markers of allograft function for future interventional trials in transplantation.

Original languageEnglish
Pages (from-to)1600-1605
Number of pages6
JournalAmerican Journal of Transplantation
Issue number7
StatePublished - Jul 2005
Externally publishedYes


  • Alloantibody response
  • Allograft dysfunction
  • Kidney fibrosis
  • Nephrotoxicity
  • Polyoma virus nephropathy
  • Protocol biopsy


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