YAP controls transcriptional elongation through CKD9 recruitment for proximal pause release: “Hippo-thetical”, new therapeutic targets?

Fiorina Kyritsi; Douglas K. Price; William D. Figg

doi:10.1080/15384047.2016.1178883

YAP controls transcriptional elongation through CKD9 recruitment for proximal pause release: “Hippo-thetical”, new therapeutic targets?

Fiorina Kyritsi, Douglas K. Price, William D. Figg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

he Hippo-YAP signaling pathway has been established as a crucial regulator of tissue growth and tumorigenesis but the mechanism for transcriptional control remains unclear. In their study, Galli et al. show that YAP/TAZ binding is restricted to a small number of gene enhancers and that YAP/TAZ regulates transcriptional elongation by recruiting the Mediator complex.

Original language	English
Pages (from-to)	592-594
Number of pages	3
Journal	Cancer Biology and Therapy
Volume	17
Issue number	6
DOIs	https://doi.org/10.1080/15384047.2016.1178883
State	Published - 2 Jun 2016
Externally published	Yes

Keywords

Hippo/YAP pathway
YAP-bound regulatory elements
mediator complex
transcriptional elongation
tumorigenesis

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10.1080/15384047.2016.1178883

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title = "YAP controls transcriptional elongation through CKD9 recruitment for proximal pause release: “Hippo-thetical”, new therapeutic targets?",

abstract = "he Hippo-YAP signaling pathway has been established as a crucial regulator of tissue growth and tumorigenesis but the mechanism for transcriptional control remains unclear. In their study, Galli et al. show that YAP/TAZ binding is restricted to a small number of gene enhancers and that YAP/TAZ regulates transcriptional elongation by recruiting the Mediator complex.",

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N1 - Publisher Copyright: ©, This article not subject to US copyright law.

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Y1 - 2016/6/2

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KW - YAP-bound regulatory elements

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YAP controls transcriptional elongation through CKD9 recruitment for proximal pause release: “Hippo-thetical”, new therapeutic targets?

Abstract

Keywords

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